Food materials useful in preventing and ameliorating...

A - Human Necessities – 61 – K

Patent

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A61K 31/122 (2006.01) A23L 1/03 (2006.01) A23L 1/28 (2006.01) A23L 1/30 (2006.01) A61K 31/136 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 35/74 (2006.01) A61P 3/14 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2388243

This invention relates to drinks and foods having osteogenetic function, each of which comprises as an active ingredient an effective amount of a culture of a propionic acid bacterium and/or a lactic acid bacterium, said culture containing 2-amino-3-carboxy-1,4-naphthoquinone; and preventives and/or remedies for metabolic bone diseases, each of which comprises as an active ingredient a naphthoquinone compound selected from the group consisting of 2-amino-3-carboxy-1,4-naphthoquinone, 1,4-naphthoquinone, 2-hydroxy-1,4-naphthoquinone, 2,3-dichloro-1,4-naphthoquinone, 5-hydroxy-1,4-naphthoquinone, 8-hydroxy-1,4-naphthoquinone, 2-(.alpha.-hydroxy-6-methylpentenyl)-5,8-dihydroxy-1,4-naphthoq uinone and salts thereof. These cultures and naphthoquinones promote bone metabolism and increase bone mass and bone strength.

L'invention concerne des boissons et des aliments ayant une fonction de formation osseuse et contenant comme principe actif une quantité efficace d'une culture d'une bactérie d'acide propionique et/ou d'une bactérie d'acide lactique renfermant 2-amino-3-carboxy-1,4-naphtoquinone et des médicaments préventifs/thérapeutiques à administrer dans le traitement de maladies du métabolisme osseux contenant comme principe actif un composé de naphtoquinone sélectionné dans le groupe constitué de 2-amino-3-carboxy-1,4-naphtoquinone, 1,4-naphtoquinone, 2-hydroxy-1,4-naphtoquinone, 2,3-dichloro-1,4-naphtoquinone, 5-hydroxy-1,4-naphtoquinone, 2-(.alpha.-hydroxy-.delta.-méthylpentényl)-5,8-dihydroxy-1,4-naphtoquinone et leurs sels. La culture et les dérivés de naphtoquinone précités favorisent le métabolisme osseux, augmentant ainsi la masse osseuse et la résistance des os.

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