Form of cefuroxime ester, process for its preparation and...

Details Form of cefuroxime ester, process for its preparation and... Form of cefuroxime ester, process for its preparation and...

C - Chemistry, Metallurgy

07

D

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C07D 501/34 (2006.01) A61K 31/19 (2006.01) A61K 31/325 (2006.01) A61K 31/34 (2006.01) A61K 31/54 (2006.01) A61K 31/545 (2006.01) C07D 501/00 (2006.01) C07D 501/02 (2006.01) C07D 501/12 (2006.01) C07D 501/20 (2006.01) C07D 501/24 (2006.01) C07D 501/46 (2006.01)

Patent

CA 1240313

ABSTRACT OF THE DISCLOSURE There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime l-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration. Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described. Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.

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