Formation of triple helix complexes of double stranded dna...

Details Formation of triple helix complexes of double stranded dna... Formation of triple helix complexes of double stranded dna...

C - Chemistry, Metallurgy

07

H

195/1.12, 150/8.

C07H 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2019156

PATENT 187/ 069 ABSTRACT OF THE DISCLOSURE A specific segment of double stranded DNA may be detected or recognized by formation of a triple helix structure using an Oligomer comprised of nucleosidyl units linked by internucleosidyl phosphorus linkages. Function or expression of double stranded DNA segments may be prevented by triple helix formation. Novel Oligomers comprising modified nucleosidyl units are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.

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