C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12N 15/66 (2006.01)
Patent
CA 2119890
2119890 9307295 PCTABS00021 A specific segment of single stranded nucleic acid may be detected or recognized by formation of a triple helix structure using first and second oligomers comprised of nucleosidyl units linked by internucleosidyl phosphorus linkages. Function or expression of single stranded nucleic acid segments may be prevented by triple helix formation. Novel oligomers comprising modified nucleosidyl units are useful in triple helix formation, and may be optionally derivatized with DNA modifying groups.
Adams Thomas H.
Arnold Lyle J. Jr.
Ts'o Paul O.
Genta Incorporated
Smart & Biggar
The Johns Hopkins University
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