Forming iron nitrosyl hemoglobin

Details Forming iron nitrosyl hemoglobin Forming iron nitrosyl hemoglobin

C - Chemistry, Metallurgy

07

K

C07K 14/805 (2006.01) A01N 1/02 (2006.01) A61B 1/00 (2006.01) A61K 35/14 (2006.01) A61K 38/16 (2006.01) A61M 1/02 (2006.01) A61M 1/36 (2006.01)

Patent

CA 2509817

Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body is converted to a hemoglobin capable of nitric oxide delivery and provides vasodilator and antiplatelet activity. This provides basis for ameliorated risk blood product transfusions.

Contrairement à une idée reçue selon laquelle le nitrite oxyde généralement l'hémoglobine avec une élimination d'oxyde nitrique actif, l'hémoglobine désoxygénée réagit avec le nitrite inorganique en faible concentration pour produire de l'hémoglobine de nitrosyle de fer très stable qui, lors de son administration dans le corps, est convertie en hémoglobine permettant de fournir de l'oxyde nitrique, et présente une activité vasodilatatrice et antiplaquettaire. Ceci permet de faire diminuer les risques encourus lors de transfusions de produits sanguins.

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