Formoterol and ciclesonide aerosol formulations

Details Formoterol and ciclesonide aerosol formulations Formoterol and ciclesonide aerosol formulations

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/70 (2006.01) A61K 31/167 (2006.01) A61K 31/58 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2481187

A pharmaceutical aerosol formulation comprising particles of formoterol or a pharmaceutically acceptable salt, solvate or physiologically functional derivative thereof, said particles being suspended in the formulation; a compound of the formula (I), in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, said compound of formula (I) being dissolved in the formulation; and a propellant selected from 1,1,1,2- tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoropropane and a mixture thereof.

L'invention concerne une formulation d'aérosol pharmaceutique comprenant des particules de formoterol ou un sel pharmaceutiquement acceptable de celui-ci, un solvate ou un dérivé physiologiquement fonctionnel de celui-ci, lesdites particules étant en suspension dans la formulation. L'invention concerne un composé de formule (I), dans laquelle R¿1?représente 1-butyle, 2-butyle, cyclohéxyle ou phényle et R¿2 ?représente acétyle ou isobutanoyle, ledit composé de formule (I) étant dissous dans la formulation; et un propulseur sélectionné parmi 1,1,1,2-tétrafluoroéthanne, 1,1,1,2,3,3,3-heptafluoropropane et un mélange de ceux-ci.

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