Forms of prostate specific antigen and methods for their...

Details Forms of prostate specific antigen and methods for their... Forms of prostate specific antigen and methods for their...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 5/24 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2286090

Inactive precursor forms of PSA (pPSA) have been identified. At least one of these forms of pPSA exists in human serum. An expression vector is provided to stably express PSA, in the form of pPSA, in a mammalian system. Methods for detecting inactive precursors of PSA in human physiological fluid are provided. Antibodies specific for pPSA are also provided, as well as diagnostic kits and methods useful in the diagnosis and management of prostate cancer.

On a identifié des formes inactives de précurseur d'ASP (ASPp). Au moins une de ces formes d'ASPp existe dans du sérum humain. On utilise un vecteur d'expression pour exprimer l'ASP de manière stable sous forme d'ASPp dans un système mammifère. On décrit des procédés permettant de détecter des précurseurs inactifs d'ASP dans du fluide physiologique humain; des anticorps spécifiques contre l'ASPp ainsi que des kits de diagnostic et des procédés utiles dans le diagnostic et le traitement du cancer de la prostate.

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