A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 39/395 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2757306
The present invention relates, in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies and, in particular, to a formulation comprising a prehairpin intermediate form of HIV-1 envelope gp41 linked to a liposome. The invention also relates to methods of inducing broadly neutralizing anti-HIV- 1 antibodies using such a formulation.
La présente invention concerne, de façon générale, une composition utilisable en vue de l'induction de la production d'anticorps dirigés contre le VIH-1 et, en particulier, une composition comprenant une forme intermédiaire en pré-épingle à cheveux de la protéine d'enveloppe gp41 du VIH-1 reliée à un liposome. L'invention concerne également des procédés d'induction de la production d'anticorps très neutralisants contre le VIH-1 au moyen de ladite composition.
Alam Munir
Chen Bing
Harrison Stephen
Haynes Barton F.
Children's Medical Center Corporation
Duke University
Goudreau Gage Dubuc
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