Formulation and method for enhancement of gastrointestinal...

A - Human Necessities – 61 – K

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Details

A61K 45/06 (2006.01) A61K 9/48 (2006.01) A61K 31/137 (2006.01) A61K 31/4745 (2006.01) A61K 31/566 (2006.01) A61K 47/00 (2006.01) A61K 47/26 (2006.01) A61K 47/34 (2006.01) A61K 47/44 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2621037

The present invention relates to a method of enhancing absorption of a pharmaceutical agent by administering the agent in combination with an inhibitor of BCRP/ABCG2 wherein the amount of the inhibitor is about the critical micelle concentration of the inhibitor or less than the critical micelle concentration. The invention also relates to a formulation suitable for use to enhance absorption of a pharmaceutical agent. The pharmaceutical agent can be a chemotherapeutic agent. The invention also relates to capsules containing the formulation.

La présente invention se rapporte à procédés permettant d'améliorer l'absorption d'un agent pharmaceutique, qui consistent à administrer ledit agent en combinaison avec un inhibiteur de BCRP/ABCG2, la dose de l'inhibiteur étant environ égale à la concentration micellaire critique de l'inhibiteur ou inférieure cette dernière. L'invention a également trait à une préparation pouvant servir à améliorer l'absorption d'un agent pharmaceutique. Ledit agent pharmaceutique peut être un agent chimiothérapeutique. L'invention concerne également des capsules contenant ladite préparation.

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