Formulation based in heparin, glycosaminoglycan or...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/726 (2006.01) A61K 31/727 (2006.01)

Patent

CA 2409828

The invention relates to formulations based on at least one heparin, one glycosaminoglycan or on one heparinoid, and to a formulation base with a lipid constituent and a polymer constituent. The invention also relates to the use of this formulation as a medicament for orally administering at least one heparin, one glycosaminoglycan or one heparinoid, and to a method for preparing the formulations by mixing the formulation constituents while forming a plastic mixture and, optionally, while preparing the formulations as a medicament while, advantageously, using melt extrusion. The lipid constituent advantageously comprises active substance-promoting properties, whereas the polymer constituent is soluble or is capable of swelling. The invention provides that at least portions of the lipid constituent are embedded in a polymer matrix, preferably in molecularly dispersed form. The formulations can form emulsions in water or in aqueous fluids.

L'invention concerne des formulations à base d'au moins une héparine, un glysosaminoglycane ou d'un héparinoïde et d'une base de formulation avec un constituant lipide et un constituant polymère. L'invention concerne l'utilisation de cette formulation comme forme galénique pour l'administration orale d'au moins une héparine, un glycosaminoglycane ou un héparinoïde, ainsi qu'un procédé de préparation desdites formulations par mélange des constituants de la formulation afin de former un mélange plastique et éventuellement de préparer lesdites formulations sous forme galénique, avantageusement par extrusion de matière en fusion. Le constituant liquide présente avantageusement des propriétés renforçant l'effet du principe actif, alors que le constituant polymère est soluble ou apte à gonfler. A cet effet, au moins certaines parties du constituant lipide sont enrobées dans une matrice polymère, de préférence sous forme moléculairement dispersée. Dans l'eau ou dans des liquides aqueux, ces formulations peuvent former des émulsions.

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