A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61K 38/08 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2757240
The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.
La présente invention concerne, de façon générale, une composition pouvant être utilisée pour induire la production d'anticorps contre le VIH-1 et, en particulier, une composition comprenant des agonistes du récepteur de type Toll (TLR) et des conjugués associant peptides du domaine MPER de la protéine gp41 du VIH-1 et liposomes, en vue de l'induction de la production d'anticorps très réactifs contre le VIH-1. L'invention concerne également des procédés d'induction de la production d'anticorps neutralisants contre le VIH-1 au moyen de ladite composition.
Alam S. Munir
Haynes Barton F.
Sekaran Moses D.
Shen Xiaoying
Tomaras Georgia
Duke University
Goudreau Gage Dubuc
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