Formulation for use in inducing cytotoxic t-cells

Details Formulation for use in inducing cytotoxic t-cells Formulation for use in inducing cytotoxic t-cells

A - Human Necessities

61

K

A61K 39/295 (2006.01) A61K 39/05 (2006.01) A61K 39/08 (2006.01) A61K 39/10 (2006.01) A61K 39/13 (2006.01) A61K 39/245 (2006.01) C07K 14/04 (2006.01) C07K 14/045 (2006.01) C07K 14/05 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2185540

The present invention provides a composition where a CTL peptide is presented in such a way as to maximise the attachment of peptide to class 1 MHC molecules on the external surface of cells and the subsequent processing of these cells in the optimal way to induce high-affinity CD8+ CTL responses. Preferably, the composition comprises a water-in-oil formulation including at least one antigen to which the individual will mount an anamnestic response and at least one cytotoxic T-cell epitope.

Composition dans laquelle un peptide de lymphocyte T cytotoxique est présenté de manière à maximiser la fixation du peptide aux molécules du complexe majeur d'histocompatibilité de classe 1 à la surface externe des cellules, et traitement ultérieur optimisé de ces cellules dans le but d'induire des réponses de lymphocytes T cytotoxiques CD¿8??+¿ à affinité élevée. De préférence, la composition comporte une formulation eau-dans-huile comprenant au moins un antigène qui suscitera chez l'individu une réponse anamnestique, ainsi qu'au moins un épitope de lymphocyte T cytotoxique.

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