A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/352 (2006.01) A61K 36/00 (2006.01) A61K 36/48 (2006.01) A61K 36/539 (2006.01)
Patent
CA 2703698
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5- LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Unigen Inc.
Unigen Pharmaceuticals Inc.
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