A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/352 (2006.01) A61K 31/35 (2006.01)
Patent
CA 2484192
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
L'invention concerne une nouvelle composition comprenant un mélange de deux classes spécifiques de composés, des flavonoïdes et des flavanes sans noyau B, destinées à être utilisées dans la prévention et le traitement de maladies et d'états pathologiques médiés par les voies COX-2 et 5-LO. L'invention concerne de plus un nouveau procédé permettant d'inhiber simultanément l'enzyme cyclooxygénase-2 (COX-2) et 5-lipoxygénase (5-LO), et de réduire la production de cox-2 ARNm. L'invention concerne en outre un procédé de perte de poids et de contrôle du glucose dans le sang. Lesdits procédés de l'invention comprennent l'administration à un hôte, nécéssitant lesdits traitements, d'une quantité efficace de la composition de l'invention en association avec un porteur acceptable pharmaceutiquement. L'invention concerne de manière générale la prévention et le traitement de maladies et d'états pathologiques médiés par les voies cyclooxygénase-2 (COX-2) et 5-lipoxygénase (5-LO), comprenant, mais non limités à l'inconfort et à la douleur des articulations associés aux états pathologiques tels que l'ostéoarthrose, l'arthrose rhumatoïde et d'autres blessures liées à un surmenage articulaire.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Unigen Inc.
Unigen Pharmaceuticals Inc.
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