A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 31/12 (2006.01) A61K 51/12 (2006.01) B01J 13/00 (2006.01)
Patent
CA 2683777
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell.
L'invention concerne des compositions et des procédés de fabrication d'une nanoparticule polymère activée pour la libération ciblée de médicament. Cette nanoparticule contient un polymère biocompatible et un agent stabilisant amphiphile lié non covalent à un composé espaceur contenant au moins un électrophile qui réagit de façon sélective avec n'importe quel nucléophile sur un agent de ciblage et place ledit agent sur la surface extérieure d'une nano-enveloppe biodégradable, un agent actif étant chargé avec la nano-enveloppe.
Braden Arthur R.c.
Vishwanatha Jamboor K.
Braden Arthur R.c.
Shapiro Cohen
University Of North Texas Health Science Center At Fort Worth
Vishwanatha Jamboor K.
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