Formulation of amino acids and riboflavin useful to reduce...

A - Human Necessities – 61 – K

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A61K 31/195 (2006.01) A23L 1/305 (2006.01) A61K 31/198 (2006.01) A61K 31/525 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2468133

Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cytotoxic cancer chemotherapy are disclosed. The pharmaceutical compositions of the present invention comprise riboflavin, effectors of the urea cycle in free form or pharmacologically acceptable salts thereof, and amino acids selected from the gorups of essential and non-essential amino acids, in free form or pharmaceutically acceptable salts thereof, suitably combined with appropriate carriers, diluents, or excipients. Also disclosed are methods of alleviating or reducing the effects of fatigue and weakness associated with cancer and cytotoxic cancer chemotherapy by administration of pharmaceutical compositions of the present invention.

L'invention concerne des compositions pharmaceutiques efficaces pour soulager ou diminuer les effets de fatigue et de débilité liés au cancer et à la chimiothérapie du cancer cytotoxique. Les compositions pharmaceutiques de cette invention renferment de la riboflavine, des effecteurs du cycle d'urée sous forme libre ou des sels acceptables en pharmacologie, et des acides aminés sélectionnés parmi les groupes d'acides aminés essentiels et non essentiels, sous forme libre ou des sels acceptables en pharmacologie, combinés de manière appropriée à des supports, des diluants ou des excipients adéquats. Ladite invention a également trait à des méthodes permettant de soulager ou de diminuer les effets de fatigue ou de débilité liés au cancer et à la chimiothérapie du cancer cytotoxique, par le biais de l'administration de compositions pharmaceutiques susmentionnées.

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