A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/26 (2006.01) A61K 31/35 (2006.01) A61K 31/351 (2006.01) A61K 31/635 (2006.01) A61K 33/00 (2006.01) A61K 49/04 (2006.01) A61K 9/50 (2006.01)
Patent
CA 2409910
Erodible, gastric-retentive dosage forms are provided that are formulated using the in vitro drug release profile obtained with USP Disintegration test equipment rather the USP Dissolution Apparatus. The invention is premised on the discovery that the USP Disintegration Test and modified versions thereof are far more predictive of the in viva release profile for a controlled release dosage form than is the standard USP Dissolution Test, particularly controlled release dosage forms of the swellable. erodible type. The dosage forms generally comprise particles of a biocompatible, hydrophilic polymer having the active agent incorporated therein, wherein the particles are optionally but preferably compacted into a tablet or loaded into a capsule. The dosage forms can be used to deliver water-insoluble or sparingly soluble drugs as well as water-soluble drugs, providing that the latter are coated with a protective coating or contained in a protective vesicle.
Berner Bret
Louie-Helm Jenny
Depomed Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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