Formulation of stabilised cationic transfection...

Details Formulation of stabilised cationic transfection... Formulation of stabilised cationic transfection...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2278665

The invention concerns a composition containing stabilised particles of cationic transfection agent(s)/nucleic acid complexes characterised in that it includes besides said transfection agent and nucleic acid at least a non-ionic surfactant in sufficient amount for preventing the aggregation of the particles in course of time. In a preferred embodiment, the surfactant is a polyoxyalkylene or a derivative thereof.

La présente invention concerne une composition comprenant des particules de complexes agent(s) de transfection cationique(s)/acides nucléiques stabilisées caractérisée en ce qu'elle incorpore outre ledit agent de transfection et l'acide nucléique au moins un agent de surface non ionique en quantité suffisante pour prévenir l'aggrégation des particules au cours du temps. Selon un mode préféré de l'invention, l'agent de surface est ou dérive d'un polyoxyalkylène.

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