Formulation of substituted benzimidazoles

Details Formulation of substituted benzimidazoles Formulation of substituted benzimidazoles

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 47/10 (2006.01) A61K 47/30 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2425199

The present invention relates to stable liquid formulations that comprise a water free or almost water free, polyethylene glycol solution of sodium or potassium salt of a H+, K+-ATPase inhibitor of formula (I) or a sodium or potassium salt of one single enantiomer thereof. Alternatively, the sodium or potassium salt of the H+, K+-ATPase inhibitor may be formed in situ in the polyethylene glycol solution by adding sodium or potassium hydroxide together and the active compound. The invention is also directed to the preparation of the claimed formulation, use of the stable liquid formulations in medicine and in the treatment of gastrointestinal diseases.

La présente invention concerne des formulations liquides stables comprenant une solution de polyéthylène glycol, exempte d'eau ou quasiment exempte d'eau, de sel de sodium ou de potassium d'un inhibiteur de H?+¿, K?+¿-ATPase représenté par la formule (I) ou un sel de sodium ou de potassium d'un seul de ces énantiomères. Dans un autre mode de réalisation, le sel de sodium ou de potassium de l'inhibiteur de H?+¿, K?+¿-ATPase peut être formé in situ dans la solution de polyéthylène glycol par adjonction de l'hydroxyde de sodium ou de potassium ensemble et du composé actif. L'invention concerne également la préparation de ladite formulation, l'utilisation des formulations liquides stables dans des médicaments et dans le traitement de maladies gastro-intestinales.

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