Formulation of tocotrienol quinones for the treatment of...

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/05 (2006.01) A61K 31/122 (2006.01) A61P 25/02 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01)

Patent

CA 2759984

A formulation, comprising an ophthalmically effective amount of one or more tocotrienol quinones, particularly of alpha-tocotrienol quinone is disclosed. Use of a formulation comprising one or more tocotrienol quinones for the prevention, reduction, amelioration or treatment of ophthalmic disorders that are associated with a neurodegenerative or trauma disorder is also discussed. A method of treating or controlling the ocular symptoms associated with neurodegenerative diseases or trauma with a formulation comprising one or more tocotrienol quinones is also discussed. A method of treating or controlling the ocular symptoms associated with mitochondrial myopathies with a formulation comprising one or more tocotrienol quinones is also discussed.

La présente invention concerne une préparation contenant une quantité efficace, d'un point de vue ophtalmique, d'une ou de plusieurs quinones de tocotriénol, plus particulièrement la quinone d'alpha-tocotriénol. L'invention porte également sur l'utilisation d'une préparation contenant une ou plusieurs quinones de tocotriénol en vue de prévenir, réduire, améliorer ou traiter des troubles ophtalmologiques associés à un trouble neurodégénératif ou dû à un traumatisme. L'invention concerne également une méthode permettant de traiter ou maîtriser les symptômes oculaires associés aux maladies neurodégénératives ou à une lésion traumatique au moyen d'une préparation contenant une ou plusieurs quinones de tocotriénol. L'invention concerne aussi une méthode permettant de traiter ou maîtriser les symptômes oculaires associés aux myopathies mitochondriales au moyen d'une préparation contenant une ou plusieurs quinones de tocotriénol.

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