Formulation to render an antimicrobial drug potent against...

A - Human Necessities – 61 – K

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A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2523151

The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron-tomicron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 ~m as measured by laser diffractonetry.

L'invention concerne des compositions à base de particules de dimension micronique à sous-micronique d'agents antimicrobiens. Plus particulièrement, cette invention concerne une composition à base d'agents antimicrobiens qui rend l'agent efficace contre des organismes normalement considérés comme étant résistant à cet agent. La composition contient une suspension aqueuse à base de particules de dimension micronique et sous-micronique contenant l'agent revêtu d'au moins un tensioactif choisi dans le groupe constitué de: tensioactifs ioniques, tensioactifs non ioniques, tensioactifs biologiquement dérivés, acides aminés et leurs dérivés. Ces particules possèdent une dimension particulaire moyenne pondérée en fonction du volume de moins de 5 µm, mesurée par diffractométrie laser.

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