A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 9/22 (2006.01) A61K 31/35 (2006.01)
Patent
CA 2494233
Dosage forms and devices for enhancing controlled delivery of lowly soluble active agents including topiramate by use of a drug core composition that increases the solubility of the pharmaceutical agent are described. The present invention provides a drug core composition for delivering high doses of lowly soluble topiramate in solid oral drug delivery systems that are convenient to swallow, for once-a-day administration. The drug core composition contains topiramate, a surfactant and a carrier in ratios for optimal solubility and delivery.
L'invention concerne des formes posologiques et des dispositifs d'amélioration de l'administration contrôlée d'agents actifs à solubilité lente comprenant un topiramate au moyen d'une composition noyau médicamenteuse augmentant solubilité de l'agent pharmaceutique. La présente invention concerne également une composition noyau médicamenteuse permettant d'administration de fortes doses de topiramate à faible solubilité dans des systèmes d'administration de médicaments solides par voie orale qu'il faut avaler, pour une seule administration quotidienne. La composition noyau médicamenteuse contient un topiramate, un tensioactif et un support selon des rapports assurant une solubilité et une administration optimales.
Ayer Atul D.
Edgren David
Jao Frank
Lam Andrew
Li Shaoling
Alza Corporation
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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