Formulations and methods for providing prolonged local...

Details Formulations and methods for providing prolonged local... Formulations and methods for providing prolonged local...

A - Human Necessities

61

K

A61K 45/08 (2006.01) A61K 9/16 (2006.01) A61K 31/445 (2006.01) A61K 31/465 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) A61K 31/56 (2006.01) A61K 31/57 (2006.01) A61K 31/715 (2006.01) A61K 45/06 (2006.01) A61K 47/02 (2006.01) A61K 47/36 (2006.01) A61K 9/00 (2006.01)

Patent

CA 2195119

A formulation and methods for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a pharmaceutically acceptable, i.e., non-toxic, non-glucocorticoid augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent.

Les procédés et compositions décrits induisent une anesthésie locale prolongée chez un patient. On utilise à cet effet un substrat qui contient un anesthésique local et une quantité efficace d'un matériau biocompatible biodégradable de libération contrôlée qui prolonge la libération de l'anesthésique local contenu dans le substrat afin d'appliquer une anesthésie locale réversible lorsque le substrat est implanté ou injecté dans un patient. Un agent non toxique, non glucocorticoïde et pharmaceutiquement acceptable prolonge efficacement la durée de l'anesthésie locale pendant une période plus longue que celle qui résulte de l'utilisation du substrat sans cet agent de prolongation.

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