Formulations and methods of treating inflammatory bowel disease

Details Formulations and methods of treating inflammatory bowel disease Formulations and methods of treating inflammatory bowel disease

A - Human Necessities

61

K

A61K 31/655 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/50 (2006.01) A61K 31/606 (2006.01) A61P 1/06 (2006.01) C07C 245/08 (2006.01)

Patent

CA 2535923

Methods and formulations for treating inflammatory bowel disease are disclosed. The methods and formulations include methods and formulations for delivering effective concentrations of 4~aminosalicylic acid and/or 5- aminosalicylic acid to or their salts and prodrugs, such as 4,4~-azo-bis salicyclic acid affected areas of the intestine. The methods and formulations comprise modified-release elements, providing for drug delivery to the affected or desired area. Diseases and conditions treatable with the present invention include Crohn's disease and ulcerative colitis.

L'invention porte sur des formes galéniques et des méthodes de traitement contre la maladie intestinale inflammatoire. Les méthodes de traitement et les formes galéniques comportent, notamment mais pas exclusivement, des méthodes de traitement et des formes pharmaceutiques permettant d'administrer des concentrations efficaces de 4-acide aminosalicylique et/ou de 5-acide aminosalicylique aux endroits lésés de l'intestin. Les méthodes de traitement et les formes galéniques comprennent des éléments à libération modifiée, ce qui permet de diffuser le médicament directement à la zone lésée. Cette invention permet de traiter des maladies et des pathologies telles que la maladie de Crohn et la colite ulcéreuse.

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