Formulations and methods of use thereof

Details Formulations and methods of use thereof Formulations and methods of use thereof

C - Chemistry, Metallurgy

07

D

C07D 225/06 (2006.01) A61K 31/395 (2006.01) A61P 35/00 (2006.01) G01N 23/20 (2006.01)

Patent

CA 2672537

Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

L'invention concerne, entre autres, des formes solides d'analogues de geldanamycine, des compositions pharmaceutiques comprenant un analogue de geldanamycine et un inhibiteur de cristallisation, et des procédés de fabrication et d'utilisation de ces compositions. L'invention concerne en outre des méthodes de traitement du cancer, d'un;tat pathologique néoplasique et/ou d'un trouble hyperprolifératif et des procédés d'inhibition de la protéine de choc thermique 90 ('Hsp90').

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