Formulations comprising antisense nucleotides to connexins

Details Formulations comprising antisense nucleotides to connexins Formulations comprising antisense nucleotides to connexins

A - Human Necessities

61

K

A61K 31/711 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2361251

A therapeutic and/or cosmetic formulation comprising at least one anti-sense polynucleotide to a connexin protein together with a pharmaceutically acceptable carrier or vehicle is useful in site specific down regulation of connexin protein expression, particularly in reduction of neuronal cells death, wound healing, reduction of inflammation, decrease of scar formation and skin rejuvenation and thickening.

Cette invention concerne une formulation à visée thérapeutique et/ou cosmétique qui comporte au moins un polynucléotide anti-sens de connexine et un excipient ou véhicule acceptable d'un point de vue pharmaceutique. Cette formulation est utilisée pour réguler négativement l'expression de connexine sur des sites spécifiques, notamment pour lutter contre la mort des neurones et contre la formation de cicatrices, pour favoriser la cicatrisation, la réjuvénescence et l'épaississement de la peau et pour réduire l'inflammation.

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