A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/36 (2006.01) A61K 47/26 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2426334
The present invention provides formulations and methods to enhance the delivery of nucleic acids to cells. Formulations comprising dextrin polymers in combination with sugars provide enhanced delivery of nucleic acids, particularly eucaryotic expression vectors, demonstrate enhanced delivery of nucleic acids to cells in vivo. The present invention also provides methods of treatment in combination with such formulations.
La présente invention concerne des formulations et des procédés permettant d'améliorer l'introduction d'acides nucléiques dans des cellules. Des formulations comprenant des polymères de dextrine en combinaison avec des sucres améliorent l'introduction d'acides nucléiques, en particulier des vecteurs d'expression eucaryotiques, présentant une introduction améliorée d'acides nucléiques dans des cellules in vivo. La présente invention concerne également des méthodes de traitement en combinaison avec ces formulations.
Conroy Susan
Engler Heidrun
Maneval Daniel
Canji Incorporated
Gowling Lafleur Henderson Llp
Innovata Limited
Ml Laboratories Plc
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