Formulations comprising dissolved paroxetine

Details Formulations comprising dissolved paroxetine Formulations comprising dissolved paroxetine

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2310407

Pharmaceutical formulations of paroxetine are provided in which the paroxetine is in solution in a solid, semi-solid or liquid carrier. The solutions are used to fill capsules, or self-supporting solid solutions are shaped into solid dosage forms such as tablets or pellets. Also disclosed are novel liquid formulations in which a solubilising agent is used to solubilise paroxetine in oils and/or lipids, and methods of avoiding other paroxetine forms converting to the hemihydrate, by use of anhydrous or hydrophobic carriers or excipients.

L'invention concerne des formulations pharmaceutiques de paroxétine dans lesquelles la paroxétine est en solution dans un véhicule solide, semi-solide ou liquide. On utilise ces solutions afin de remplir des gélules ou on prépare des formes galénique solides, telles que des comprimés ou des granules, à partir de solutions solides seules. Elle concerne également de nouvelles formulations liquides dans lesquelles on utilise un agent solubilisant afin solubiliser la paroxétine, soit dans des huiles, soit dans des lipides, ainsi que des procédés permettant d'éviter la conversion d'autres formes de paroxétine en son hémihydrate, par l'intermédiaire de véhicules anhydres ou hydrophobes.

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