Formulations containing an immune response modifier

Details Formulations containing an immune response modifier Formulations containing an immune response modifier

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2534313

Pharmaceutical formulations in an aqueous (preferably, sprayable) formulaiton including an immune response modifier (IRM), such as those chosen from imidazoquinoline amines, tetrahydroimidazoquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, imidazonaphthyridine amines, imidazotetrahydronaphthyridine amines, oxazoloquinoline amines, thiazoloquinoline amines, oxazolopyridine amines, thiazolopyridine amines, oxazolonaphthyridine amines, thiazolonaphthyridine amines, and 1H-imidazo dimers fused to pyridine amines, quinoline amines, tetrahydroquinoline amines, naphthyridine amines, or tetrahydronaphthyridine amines, are provided. In one embodiment, the aqueous formulations are advantageous for treatment and/or prevention of allergic rhinitis, viral infections, sinusitis, and asthma.

L'invention concerne des préparations pharmaceutiques dans une préparation aqueuse (de préférence vaporisable) comprenant un modificateur de la réponse immunitaire (IRM), tel que ceux choisis parmi les amines imidazoquinoléines, les amines tétrahydroimidazoquinoléines, les amines imidazopyridines, les amines cycloalkylimidazopyridines fusionnées en 6,7, les amines imidazoquinoléines pontées en 1,2, les amines imidazonaphthyridines, les amines imidazotétrahydronaphthyridines, les amines oxazoloquinoléines, les amines thiazoloquinoléines, les amines oxazolopyridines, les amines thiazolopyridines, les amines oxazolonaphthyridines, les amines thiazolonapthyridines, et les 1<I>H</I>-imidazo dimères fusionnés aux amines pyridines, aux amines quinoléines, aux amines tétrahydroquinoléines, aux amines naphthyridines ou aux amines tétrahydronaphthyridines. Dans un mode de réalisation, les préparations aqueuses de l'invention sont avantageuses pour le traitement et/ou la prévention de la rhinite allergique, d'infections virales, de la sinusite et de l'asthme.

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