Formulations containing large-size carrier particles for dry...

Details Formulations containing large-size carrier particles for dry... Formulations containing large-size carrier particles for dry...

A - Human Necessities

61

K

A61K 9/14 (2006.01)

Patent

CA 2732585

A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Linvention concerne un inhalateur à poudre sèche comprenant une chambre à médicament conçue pour contenir une formulation incluant des particules porteuses et des particules de principe actif, un embout buccal conçu pour diriger le flux de particules de principe actif vers un utilisateur, et un organe de retenue proximal à lembout buccal. Lorgane de retenue a une forme et une disposition déterminées de manière à empêcher lécoulement pour lessentiel de toutes les particules porteuses vers lutilisateur tout en permettant lécoulement des particules de principe actif vers lutilisateur. Linhalateur peut inclure une formulation comprenant des particules porteuses permettant de délivrer le principe actif au système pulmonaire dun patient. Les particules porteuses sont susceptibles davoir un diamètre moyen de particule supérieur à environ 500 µm. Les particules porteuses peuvent être en polystyrène, PTFE, verre de silicone, et gel de silice ou en verre.

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