Formulations containing pyridazine compounds

Details Formulations containing pyridazine compounds Formulations containing pyridazine compounds

A - Human Necessities

61

K

A61K 31/501 (2006.01) A61K 31/506 (2006.01) A61P 25/28 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2650625

The invention relates to chemical compounds, compositions and methods of making and using the same. In particular, the invention provides selected pyridazine compounds of the formula (I) are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, =0, =S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.

L'invention concerne des composés chimiques, des compositions et des procédés de fabrication et d'utilisation de ceux-ci. En particulier, l'invention concerne des composés de pyridazine sélectionnés de formule I, dans laquelle R1, R4, R5, R6, R7, R8, R9, R12, R13 et R14 sont indépendamment un hydrogène, un hydroxyle, un alkyle, un alcényle, un alcynyle, un alkylène, un alcénylène, un alcoxy, un alcényloxy, un cycloalkyle, un cycloalcényle, un cycloalcynyle, un cycloalcoxy, un aryle, un aryloxy, un arylalcoxy, un aroyle, un hétéroaryle, un groupe hétérocyclique, un acyle, un acyloxy, un amino, un imino, un azido, un thiol, un thioalkyle, un thioalcoxy, un thioaryle, un nitro, un cyano, un halogéno, un sulfate, un sulfényle, un sulfinyle, un sulfonyle, un sulfonate, un sulfoxyde, un silyle, un silyloxy, un silylalkyle, un silylthio, =O, =S, un phosphonate, un uréido, un carboxyle, un carbonyle, un carbamoyle ou un carboxamide; et X est un pyrimidinyle ou un pyridazinyle éventuellement substitué, un isomère, un sel acceptable du point de vue pharmaceutique ou un dérivé de ceux-ci. L'invention concerne en outre des compositions comprenant les composés et des procédés d'utilisation des composés et compositions pour la modulation de voies cellulaires, pour le traitement ou la prévention de maladies inflammatoires, pour des applications de recherche, de criblage de médicaments et de thérapie.

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