A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61L 27/00 (2006.01) A61L 27/22 (2006.01) A61L 27/26 (2006.01)
Patent
CA 2169362
A composition is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein; a porous particulate polymer matrix; an osteogenic protein-sequestering amount of blood clot; and a calcium sulfate hemihydrate-containing substance. Also disclosed are formulations of bone morphogenetic proteins with improved solubility and/or stability characteristics.
L'invention concerne une composition comprenant un mélange pharmaceutiquement acceptable d'une protéine ostéogénique, d'une matrice polymère poreuse particulaire, d'une quantité de sang coagulé séquestrant la protéine ostéogénique et d'une substance contenant un hémihydrate de sulfate de calcium. Elle concerne également des formulations de protéines osseuses morphogénétiques présentant des caractéristiques améliorées de solubilité et/ou de stabilité.
Desouza Patrick Joseph
Huberty Michael C.
Kenley Richard A.
Northey Richard P. Jr.
Philbrook C. Michael
Genetics Institute Llc
Gowling Lafleur Henderson Llp
LandOfFree
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