A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/10 (2006.01) A61K 31/195 (2006.01) A61K 31/215 (2006.01) A61K 31/351 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01) A61K 47/16 (2006.01) A61P 31/16 (2006.01)
Patent
CA 2704778
A composition is described having improved oral permeability of polar agents such as neuraminidase inhibitors. The composition includes one or more polar agents and one or more permeability enhancers such that the composition increases the amount of the polar agent capable of being transported across a Caco-2 cell membrane by at least 150% relative to the amount capable of being transported across the Caco-2 Cell membrane in the absence of the permeability enhancer. Oral dosage forms including the composition, and methods of treating or preventing influenza infection are also provided.
L'invention porte sur une composition présentant une perméabilité orale améliorée pour des agents polaires tels que les inhibiteurs de la neuraminidase. Ladite composition inclut un ou des agents polaires et un ou des renforceurs de perméabilité, tels que la composition augmente la quantité d'agents polaires pouvant être transportés à travers une membrane cellulaire Caco-2 d'au moins 150 % par rapport à la quantité pouvant être transportés à travers une membrane cellulaire Caco-2 en l'absence de renforceurs de perméabilité. L'invention porte également sur des formes posologiques orales comportant ladite composition, et sur des méthodes de traitement ou prévention d'infections grippales.
Hite Michael
Holmes Eric
Borden Ladner Gervais Llp
Scolr Pharma Inc.
The University Of Hawaii
LandOfFree
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