Formulations for enhanced mucosal delivery of pyy

Details Formulations for enhanced mucosal delivery of pyy Formulations for enhanced mucosal delivery of pyy

A - Human Necessities

61

K

A61K 47/10 (2006.01) A61K 38/17 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2614619

Pharmaceutical formulations are described for enhancing mucosal delivery of peptide YY (PYY) to a mammal. A PYY dosage form is described that is suitable for multi-use administration. The PYY dosage form comprises a bottle containing an aqueous pharmaceutical formulation and an actuator effective intranasal administration of the formulation. The formulation comprises a therapeutically effective amount of PYY, a buffer to control pH, a water- miscible polar organic solvent and a chelating agent for cations. The PYY dosage form exhibits at least 90% PYY recovery after storage as used for greater than about five days.

L'invention concerne des formulations pharmaceutiques permettant d'améliorer l'administration par les muqueuses du peptide YY (PYY) chez un mammifère. L'invention concerne également une forme posologique du PYY adaptée pour une administration multi-usage. La forme posologique du PYY comprend un flacon contenant une formulation pharmaceutique aqueuse et un dispositif de commande d'administration intranasale efficace de la formulation. Ladite formulation contient une quantité efficace d'un point de vue thérapeutique de PYY, un tampon de régulation du pH, un solvant organique polaire miscible dans l'eau, et un agent de chélation des cations. La forme posologique du PYY présente au moins 90 % de récupération de PYY après stockage lorsqu'elle est utilisée pendant plus d'environ cinq jours.

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