Formulations for stabilizing of igm antibodies

Details Formulations for stabilizing of igm antibodies Formulations for stabilizing of igm antibodies

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 47/02 (2006.01) A61K 47/18 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2049342

2049342 9011091 PCTABS00002 Compositions suitable for intraveneous injection are disclosed, which comprise a stabilizing buffer solution containing IgM antibodies. The compositions are effective in stabilizing the antibodies in solution, inhibiting precipitation and the formation of particulates in the final product vial, while maintaining a high level of immunoreactivity. The compositions can be lyophilized to form dry, stable products which can be readily reconstituted to provide injectable, particle-free antibody solutions.

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