A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/24 (2006.01) A61K 9/107 (2006.01) A61K 31/7048 (2006.01) A61K 45/06 (2006.01) A61K 45/08 (2006.01) A61K 47/14 (2006.01) A61P 31/10 (2006.01) A61P 33/02 (2006.01)
Patent
CA 2688036
The present application relates to an oral formulation of amphotericin B and other therapeutic agents, which formulation comprises one or more fatty acid glycerol esters and one or more PEG modified phospholipids or fatty acid esters. The formulation provides enhanced bioavailability and/or increased stability of the therapeutic agent at the low pH found in gastric fluid.
La présente invention concerne une formulation orale d'amphotéricine B et d'autres agents thérapeutiques qui comprend au moins un ester de glycérol d'acide gras et au moins un phospholipide modifié par PEG ou des esters d'acide gras. La formulation engendre une biodisponibilité améliorée et/ou une stabilité accrue de l'agent thérapeutique à un niveau du pH faible propre au liquide gastrique.
Wasan Ellen K.
Wasan Kishor M.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The University Of British Columbia
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