Formulations for topical use

A - Human Necessities – 61 – K

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A61K 47/22 (2006.01) A61K 8/25 (2006.01) A61K 8/67 (2006.01) A61K 8/92 (2006.01) A61K 9/06 (2006.01) A61K 31/4174 (2006.01) A61P 31/10 (2006.01) A61Q 17/04 (2006.01)

Patent

CA 2265815

A formulation for topical use comprising a lipophilic phase which includes vitamin E or a pharmaceutically acceptable ester thereof, preferably vitamin E acetate, amongst its components, generally in an amount of from 20 to 100 %, preferably from 51 to 100 %, based on the weight of the lipophilic phase; the latter phase may also contain animal, vegetable or synthetic fats and oils or mineral oils. The ointment may be in the form of an oil, ointment, cream, hydrophobic gel, or paste. The vitamin E acetate is used as an excipient or as a component of excipients for pharmaceutical formulations for topical use.

Cette formulation destinée à un usage topique comprend une phase lipophile comprenant parmi ses constituants, de la vitamine E ou un ester de celle-ci, acceptable sur le plan pharmacologique, de préférence de l'acétate de vitamine E, généralement selon une dose représentant 20 à 100 % et préférablement 51 à 100 % du poids de la phase lipophile, laquelle phase peut également contenir des graisses et huiles animales, végétales ou synthétiques, ou des huiles minérales. Cette pommade peut se présenter sous la forme d'huile, d'onguent, de crème, de gel hydrophobe ou de pâte. On utilise l'acétate de vitamine E, en tant qu'excipient ou en tant que constituant d'excipients, dans des formulations pharmaceutiques à usage topique.

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