Formulations for treating or preventing mucositis

Details Formulations for treating or preventing mucositis Formulations for treating or preventing mucositis

A - Human Necessities

61

K

A61K 31/65 (2006.01) A61P 1/00 (2006.01) A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2381203

Mucositis is treated and/or prevented by administrating to a patient a formulation comprising a tetracycline that is poorly absorbed from the gastro-intestinal tract. The tetracycline may be in the form of a pharmaceutically acceptable salt or a base. The formulations may optionally also contain an antifungal agent to prevent fungal overgrowth due to reduction in the normal oral flora by the tetracycline. Such compositions have the advantage of treating the entire gastro-intestinal tract since the active ingredient is not removed from the tract via absorption. Further, such compositions minimize systemic exposure and accompanying side effects.

On traite et/ou on prévient l'inflammation d'une muqueuse par administration d'une formulation à un patient, ladite formulation comprenant une tétracycline faiblement absorbée par les voies gastro-intestinales. La tétracycline peut se présenter sous la forme d'un sel ou d'une base pharmaceutiquement acceptable. Les formulations peuvent éventuellement contenir un agent antifongique qui empêche la prolifération fongique due à une réduction de la flore orale normale par la tétracycline. Ces compositions présentent l'avantage de traiter la totalité des voies gastro-intestinales du fait que l'ingrédient actif n'est pas éliminé desdites voies gastro-intestinales via une absorption. Elles permettent, en outre, de réduire l'exposition systémique et les effets secondaires associés.

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