Formulations for treatment of adipose tissue, cutaneous...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 9/14 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2666564

Compositions, formulations, methods, and systems for treating regional fat deposits and fat-related conditions, dermal conditions, and muscular conditions. Methods comprise administering a composition comprising at least one compound that reduces desensitization of beta adrenergic receptors, for example a glucocorticosteroid, and/or at least one long-acting beta-2 adrenergic receptor agonist, for example, formoterol. Compositions to be administered include sustained release formulations comprising at least one long-acting beta-2 adrenergic receptor agonist, at least one compound that reduces desensitization of beta adrenergic receptors, or both in a sustained crystalline microparticle form.

L'invention concerne des compositions, des formulations, des procédés et des systèmes pour le traitement de dépôts graisseux régionaux, d'états pathologiques liés à la graisse, et de troubles dermiques et musculaires. Les procédés comprennent l'administration d'une composition renfermant au moins un composé qui réduit la désensibilisation des récepteurs bêta-adrénergiques, par exemple un glucocorticostéroïde, et/ou au moins un agoniste du récepteur bêta-adrénergique 2 à action prolongée, par exemple le formotérol. Les compositions à administrer comprennent des formulations à libération prolongée renfermant au moins un agoniste du récepteur bêta-2-adrénergique à action prolongée et/ou au moins un composé qui réduit la désensibilisation des récepteurs bêta-adrénergiques dans une forme retard de microparticules cristallines.

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