Formulations of 5-fluorocytosine and uses thereof

Details Formulations of 5-fluorocytosine and uses thereof Formulations of 5-fluorocytosine and uses thereof

A - Human Necessities

61

K

A61K 31/513 (2006.01) A61K 9/22 (2006.01) A61K 38/50 (2006.01) A61K 47/30 (2006.01) A61P 31/10 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2724740

The disclosure provides an extended release formulation of 5- fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5- fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine.

Linvention concerne une formulation à libération prolongée de 5-fluorocytosine. Selon un autre aspect, linvention concerne un procédé de traitement dune maladie fongique. Le procédé comprend ladministration à un sujet en ayant besoin dune quantité efficace pour traiter un champignon dune composition comprenant de la 5-fluorocytosine. Selon un autre aspect, linvention concerne un procédé de traitement dun cancer. Le procédé comprend ladministration à un sujet en ayant besoin dune quantité suffisante dun vecteur dexpression pour induire lexpression dune cytosine désaminase qui est capable de transformer la 5-fluorocytosine en 5-fluorouracil dans les cellules du cancer et dune quantité efficace pour traiter le cancer dune composition comprenant de la 5-fluorocytosine.

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