A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 9/54 (2006.01) A61K 9/66 (2006.01) A61K 31/216 (2006.01)
Patent
CA 2491543
A fibrate oral formulation with improved bioavailability when compared to commercially available formulations containing a therapeutically effective dose of fenofibrate or a fenofibrate derivative dissolved in N-alkyl derivative of 2-pyrrolidone, ethylene glycol monoether, C8-12 fatty acid ester of polyethylene glycol, fatty acids, or combinations thereof useful for the treatment of hypercholesterolaemia or hypertriglyceridaemia in mammals.
Une formulation orale à base de fibrates a une biodisponibilité plus élevée en comparaison aux formulations disponibles dans le commerce; elle contient une dose de fénofibrate ou de dérivés de fénofibrate, efficace du point de vue thérapeutique et dissoute dans un dérivé N-alkyle de 2-pyrrolidone, un monoéther d'éthylèneglycol, un ester d'acide gras C¿8-12? de polyéthylèneglycol, des acides gras ou leurs combinaisons. Elle peut s'utiliser dans traitement d'hypercholestérolémie ou d'hypertriglyceridémie chez les mammaliens.
Burnside Beth A.
Ibrahim Scott A.
Shojaei Amir H.
Burnside Beth A.
Ibrahim Scott A.
Shire Laboratories Inc.
Shojaei Amir H.
Smart & Biggar
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