Formulations of guanylate cyclase c agonists and methods of use

Details Formulations of guanylate cyclase c agonists and methods of use Formulations of guanylate cyclase c agonists and methods of use

A - Human Necessities

61

K

A61K 9/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2745694

The invention provides novel formulations of guanylate cyclase-C("GCC") agonist peptides and methods for their use in the treatment of gastrointestinal diseases and disorders, including gastrointestinal cancer. The GCC agonist formulations of the invention can be administered either alone or in combination with one or more additional therapeutic agents, preferably an inhibitor of cGMP-dependent phosphodiesterase or a laxative.

L'invention porte sur de nouvelles formulations de peptides d'agoniste de guanylate cyclase C (« GCC ») et sur leurs méthodes dutilisation pour le traitement de maladies et de troubles gastro-intestinaux, comprenant le cancer gastro-intestinal. Les formulations d'agoniste de GCC de l'invention peuvent être administrées soit seules soit en combinaison avec un ou plusieurs agents thérapeutiques supplémentaires, de préférence un inhibiteur de la phosphodiestérase dépendante du GMPc ou un laxatif.

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