Formulations of hyaluronic acid for delivery of osteogenic...

A - Human Necessities – 61 – L

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A61L 27/22 (2006.01) A61K 9/00 (2006.01) A61K 38/18 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61L 27/20 (2006.01) A61L 27/46 (2006.01)

Patent

CA 2386408

An injectable formulation is disclosed for delivery of osteogenic proteins. The formulation comprises a pharmaceutically acceptable admixture of an osteogenic protein; and formulations comprising osteogenic protein, hyaluronic acid derivatives and tricalcium phosphate are also disclosed. Methods for formulating porous injectable gels and pastes from hyaluronic acid are also disclosed.

Cette invention a trait à une formulation injectable aux fins de l'administration de protéines ostéogènes. Cette formulation renferme un mélange, acceptable du point de vue pharmaceutique, d'une protéine ostéogène. L'invention concerne également des formulations renfermant une protéine ostéogène, des dérivés d'acide hyaluronique et du phosphate tricalcique. Elle porte, de surcroît, sur des méthodes de formulation de pâtes et de gels poreux injectables à partir de l'acide hyaluronique.

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