A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2551896
The present invention provides a method for producing a less-painful immunogenic composition of a hydrophobic protein in a pharmaceutically acceptable carrier suitable for administering to a mammal, comprising the steps of (a) solubilizing said hydrophobic protein with a zwitterionic detergent to make a first composition; (b) altering said first composition, such that the altered composition produces a reduction in pain as measured in the rat footpad model as compared to said first composition.
La présente invention concerne une méthode de production d'une composition immunogénique moins douloureuse d'une protéine hydrophobe dans un excipient acceptable d'un point de vue pharmaceutique adapté pour être administré à un mammifère, consistant (a) à solubiliser ladite protéine hydrophobe avec un détergent zwitterionique afin d'obtenir une première composition; et (b) à modifier ladite première composition, de manière que la composition modifiée permette une réduction de la douleur telle que mesurée dans le pied d'un rat par rapport à ladite première composition.
Hagen Michael
Hoiseth Susan Kay
Matsuka Yury Vladimirovich
Metcalf Thomas Newell III
Smart & Biggar
Wyeth
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