Formulations of lymphokines and method of use thereof for...

Details Formulations of lymphokines and method of use thereof for... Formulations of lymphokines and method of use thereof for...

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 9/00 (2006.01) A61K 38/19 (2006.01) A61K 47/30 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2449288

Therapeutic formulations comprising an effective amount of IL-2 or other lymphokine and a biodegradable polymeric carrier having reverse gelation properties and the methods of use thereof for local or both local and systemic control of proliferative cell disorders are disclosed. The formulation can be administered intratumorally/peritumorally and forms an IL-2 containing depot. The IL-2-containing depot provides for continuous, prolonged release of IL-2 sufficient to stimulate the production of cytotoxic T lymphocytes which function both locally and systemically, without causing unacceptable side effects.

L'invention concerne des préparations thérapeutiques comprenant une quantité efficace d'IL-2 ou d'une autre lymphokine et un autre excipient polymère biodégradable possédant des propriétés de gélification inversées, ainsi que des procédés d'utilisation de ces formulations pour la maîtrise localisée ou à la fois localisée et systémique de troubles liés à des cellules proliférantes. La préparation peut être administrée dans la tumeur ou autour de celle-ci et forme un site tissulaire de stockage contenant IL-2. Ce site tissulaire de stockage contenant IL-2 permet la libération continue et prolongée de IL-2, laquelle est suffisante pour stimuler la production de lymphocytes T cytotoxiques ayant une fonction à la fois localisée et systémique, sans provoquer des effets secondaires inacceptables.

Affiliated with

Also associated with

Rating

Formulations of lymphokines and method of use thereof for... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Formulations of lymphokines and method of use thereof for..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Formulations of lymphokines and method of use thereof for... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1484084