Formulations of mast cell stabilizing agents for delivery to...

A - Human Necessities – 61 – K

Patent

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A61K 9/20 (2006.01) A61K 9/02 (2006.01) A61K 9/08 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2607272

Diseases of the colon are treated by oral ingestion of a unit dosage form , containing a mast cell stabilizer as an active agent. The dosage form is targeted for, delivery of the active agent to the colon or when in an immediate release formulation, such as a fast-dissolving tablet, powder or effervescent, the targeted release is upon ingestion. The dosage form comprise at least one mast cell stabilizer such as but not limited to ketotifen, nedocromil sodium, cromolyn sodium, and antihistamines which have mast cell stabilizing properties such as, but not limited, to azestastine hydrochloride and olopatadine hydrochloride, which remains intact until the dosage form reaches the colon or until ingestion.

L'invention se rapporte à une méthode de traitement des maladies du côlon par ingestion orale d'une forme galénique unitaire contenant un stabilisateur de membrane en tant que principe actif. Cette forme galénique est conçue pour permettre l'administration ciblée du principe actif dans le côlon ou, lorsqu'elle se présente sous forme d'une préparation à libération immédiate telle qu'un comprimé à dissolution rapide, une poudre ou un produit effervescent, la libération ciblée se produit à l'ingestion. Cette forme galénique contient au moins un stabilisateur de membrane mastocytaire, qui peut comprendre notamment, mais non exclusivement, le kétotifène, le nédocromile sodique, la cormolyne sodique, et des antihistaminiques présentant des propriétés de stabilisation de la membrane notamment, mais non exclusivement, le chlorhydrate d'azélastine, et le chlorhydrate d'olopatadine, qui restent intacts jusqu'à ce que la forme posologique arrive dans le côlon ou jusqu'à l'ingestion.

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