Formulations of vitamin k analogs for topical use

Details Formulations of vitamin k analogs for topical use Formulations of vitamin k analogs for topical use

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 31/122 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2718262

The present invention provides topical formulations containing a vitamin K analog, e.g., menadione, that deliver a uniform, therapeutically effective concentration of the vitamin K analog to the skin in a vehicle which is stable, non-irritating, non- drying and cosmetically acceptable. These topical formulations are useful for the treatment and prevention of dermatological conditions associated with inflammation, particularly, dermatological conditions resulting from anti-EGFR therapies.

Linvention concerne des formulations topiques contenant un analogue de vitamine K, par exemple de la ménadione, qui livre une concentration uniforme et thérapeutiquement efficace de lanalogue de vitamine K à la peau dans un véhicule qui est stable, non irritant, non séchant et cosmétiquement acceptable. Ces formulations topiques sont utiles pour le traitement et la prévention daffections dermatologiques associées à une inflammation, des affections dermatologiques résultant de thérapies anti-EGFR.

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