Formulations providing three distinct releases

Details Formulations providing three distinct releases Formulations providing three distinct releases

A - Human Necessities

61

K

167/155, 167/227

A61K 31/47 (2006.01) A61K 9/40 (2006.01) A61K 9/50 (2006.01)

Patent

CA 1264296

AHP-8516-1-Cl -32- ABSTRACT A therapeutic preparation consisting of three groups of spheroids containing an active medicinal substance. The first group of spheroids is uncoated and rapidly disintegrates upon ingestion to release an initial dose of medicinal substance a second group of spheroids is coated with a pH sensitive coat to provide a second dose and a third group of spheroids is coated with a pHindependent coat to provide a third dose. A powder blend of active medicinal substance may be substituted for the first group of uncoated spheroids. The therapeutic preparation may be utilized as a mixture of groups of spheroids in a capsule.

508440

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