C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) A61P 35/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2740134
The invention relates to antibodies or fragments thereof specific for insulin- like growth factor binding protein-7 (IGFBP7). A method of raising anti-IGFBP7 single domain antibodies is also disclosed and specific antibody clones are described, along with their binding characteristics. The anti-IGFBP7 antibodies may be useful as diagnostic tools for detecting neo-plastic diseases involving tumor angiogenesis, and a variety of other angiogenesis associated diseases.
Linvention concerne des anticorps ou des fragments de ceux-ci, spécifiques de la protéine liant le facteur de croissance de type insuline 7 (IGFBP7). Un procédé de production danticorps anti-IGFBP7 à un seul domaine, est également décrit et des clones spécifiques danticorps sont proposés, avec leurs caractéristiques de liaison. Les anticorps anti-IGFBP7 peuvent être utiles comme outils diagnostiques pour la détection de maladies néoplasiques impliquant langiogenèse de tumeurs, et une série dautres maladies associées à langiogenèse.
Abulrob Abedelnasser
Moreno Maria
Stanimirovic Danica
National Research Council Of Canada
Nelligan O'brien Payne Llp
LandOfFree
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