A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/32 (2006.01) A61K 39/395 (2006.01) A61K 47/02 (2006.01) A61K 9/08 (2006.01)
Patent
CA 2615731
Disclosed is a stable pharmaceutically acceptable formulation containing a pharmaceutically acceptable amount of a protein. Also disclosed are methods for preparing such formulations and methods for inhibiting protein aggregate formation induced by physical stresses associated with processing, manufacture, shipping, and storing protein formulations, particularly freeze/thaw stress.
L'invention concerne une formulation stable acceptable sur le plan pharmaceutique contenant une dose acceptable sur le plan pharmaceutique d'une protéine. L'invention concerne également des méthodes de préparation desdites formulations et des méthodes permettant d'inhiber la formation d'agrégats de protéines induite par des contraintes physiques associées au traitement, à la fabrication, au transport, et au stockage de formulations de protéines, en particulier la contrainte au gel/dégel.
Brych Stephen R.
Matsumura Masazumi
Amgen Inc.
Gowling Lafleur Henderson Llp
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